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IL6/STAT3 co-opts ER regulatory elements to drive metastasis in breast cancer

Siersbaek Rasmus , Scabia Valentina , Chernukhin Igor , Papachristou Eva , Broome Rebecca , Green Andrew R , Joosten Stacey , Kumar Sanjeev , Alvarez Ruben , Nagarajan Sankari , Glont Silvia , Omarjee Soleilmane , Aitken Sarah , Kishore Kamal , Rakha Emad , D'Santos Clive , Zwart Wilbert , Russell Alasdair , Brisken Cathrin , Carroll Jason S

Interleukin 6 (IL6) signaling has been associated with an aggressive and metastatic phenotype in multiple solid tumors including breast cancer, but its mechanism of action in mediating tumor progression and treatment response is not clear. By exploiting a clinically relevant intraductal xenograft model of estrogen receptor positive (ER+) breast cancer, we demonstrate that IL6 increases both primary tumor growth and distant metastases. By integrating pre-clinical models and cli...

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Oncology Abstracts

IL6/STAT3 co-opts ER regulatory elements to drive metastasis in breast cancer

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